The Video Settings section is at the bottom of the default screen of Handbrake. You should be able to see it by clicking on the Video settings tab as show below.
You can then make some alterations to the video encoding options.
For example you can set at Target Size for a video in Megabytes or as kilobits per second (kbps).
For a 10 minute video you may want to set a limit of 100M. You would do this by entering '10' in the 'Target Size' field :
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